Neal S Young Selected Research

Bone Marrow Failure Disorders

11/2022	Oligoclonal T-cell expansion in a patient with bone marrow failure after CD19 CAR-T therapy for Richter-transformed DLBCL.
1/2022	Long-term eltrombopag for bone marrow failure depletes iron.
1/2021	Minimal role of interleukin 6 and toll-like receptor 2 and 4 in murine models of immune-mediated bone marrow failure.
1/2019	Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.
1/2019	Interleukin-18 plays a dispensable role in murine and likely also human bone marrow failure.
1/2018	Circulating exosomal microRNAs in acquired aplastic anemia and myelodysplastic syndromes.
1/2018	PD-1 deficiency augments bone marrow failure in a minor-histocompatibility antigen mismatch lymphocyte infusion model.
12/2017	Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells.
10/2017	Rapamycin is highly effective in murine models of immune-mediated bone marrow failure.
1/2016	PPARγ antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function.

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Neal S Young Research Topics

Disease

81	Aplastic Anemia (Anemia, Hypoplastic) 01/2022 - 02/2002
34	Bone Marrow Failure Disorders 11/2022 - 08/2002
21	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2022 - 04/2002
19	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 01/2022 - 05/2002
10	Pancytopenia 01/2021 - 04/2002
9	Neoplasms (Cancer) 01/2018 - 02/2006
9	Infections 11/2017 - 08/2002
7	monosomy Chromosome 7 12/2021 - 12/2002
7	Cytopenia 12/2020 - 01/2002
7	Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita) 10/2014 - 11/2003
6	Inflammation (Inflammations) 12/2020 - 08/2002
5	Hematologic Neoplasms (Hematological Malignancy) 01/2022 - 06/2004
5	VEXAS syndrome 01/2022 - 12/2020
5	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 05/2006
5	Liver Diseases (Liver Disease) 01/2019 - 10/2009
5	Pulmonary Fibrosis (Fibrosing Alveolitis) 10/2014 - 11/2009
5	Graft vs Host Disease (Graft-Versus-Host Disease) 07/2014 - 05/2006
4	Fibrosis (Cirrhosis) 12/2020 - 11/2009
4	Aneuploidy (Aneuploid) 01/2019 - 03/2012
4	Chromosome Aberrations (Chromosome Abnormalities) 03/2014 - 10/2003
4	Hemolysis 07/2010 - 09/2006
3	Large Granular Lymphocytic Leukemia 11/2022 - 08/2002
3	Hematologic Diseases (Blood Diseases) 01/2022 - 10/2006
3	Thrombocytopenia (Thrombopenia) 10/2021 - 02/2008
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2016 - 01/2009
3	Necrosis 04/2015 - 04/2002
3	Genomic Instability 03/2012 - 01/2004
3	Thrombosis (Thrombus) 07/2010 - 03/2005
3	Pure Red-Cell Aplasia 03/2010 - 02/2006
3	Fatigue 06/2008 - 09/2006
2	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 01/2022 - 07/2013
2	Sickle Cell Anemia (Hemoglobin S Disease) 08/2021 - 01/2017
2	Anemia 01/2018 - 02/2008
2	Bronchiolitis Obliterans Syndrome 03/2017 - 10/2013
2	Leukemia 01/2013 - 01/2007
2	Erythema Infectiosum (Fifth Disease) 10/2011 - 05/2003
2	Congenital Bone Marrow Failure Syndromes 05/2011 - 08/2007
2	Dengue (Dengue Fever) 12/2007 - 09/2006
2	Body Weight (Weight, Body) 02/2006 - 08/2002

Drug/Important Bio-Agent (IBA)

23	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2021 - 03/2003
20	Antilymphocyte Serum (Anti-Thymocyte Globulin)IBA 01/2021 - 08/2002
16	Proteins (Proteins, Gene)FDA Link 01/2019 - 04/2002
16	telomerase RNA (bTR)IBA 01/2016 - 08/2003
14	eltrombopag FDA Link 01/2022 - 07/2012
14	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2019 - 03/2005
9	AntigensIBA 01/2018 - 04/2002
8	Thrombopoietin (c-mpl Ligand)IBA 01/2022 - 11/2003
8	CytokinesIBA 01/2019 - 01/2002
6	RNA (Ribonucleic Acid)IBA 11/2022 - 04/2005
6	EnzymesIBA 10/2021 - 11/2009
6	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2016 - 09/2002
5	VaccinesIBA 08/2021 - 09/2006
5	Biomarkers (Surrogate Marker)IBA 01/2019 - 12/2007
5	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2018 - 05/2002
5	MicroRNAs (MicroRNA)IBA 01/2018 - 02/2006
5	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 01/2014 - 10/2003
5	eculizumab FDA Link 07/2010 - 09/2006
5	Interferon-gamma (Interferon, gamma)IBA 01/2010 - 08/2002
5	Mitochondrial DNA (mtDNA)IBA 08/2007 - 04/2003
4	AntibodiesIBA 07/2018 - 04/2002
4	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 03/2017 - 09/2006
4	Transcription Factors (Transcription Factor)IBA 01/2016 - 05/2006
4	Complement System Proteins (Complement)IBA 12/2015 - 12/2004
4	thymoglobulin FDA Link 05/2015 - 01/2011
4	Monoclonal AntibodiesIBA 03/2010 - 11/2003
3	IronIBA 01/2022 - 01/2002
3	InterferonsIBA 01/2019 - 04/2015
3	Methotrexate (Mexate)FDA LinkGeneric 01/2016 - 05/2006
3	Pharmaceutical PreparationsIBA 01/2015 - 04/2007
3	Mycophenolic Acid (Cellcept)FDA LinkGeneric 10/2013 - 05/2006
3	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 07/2010 - 09/2006
3	Daclizumab (Zenapax)FDA Link 03/2010 - 11/2003
3	Fas Ligand Protein (Fas Ligand)IBA 04/2009 - 12/2002
3	Complement Inactivating AgentsIBA 02/2008 - 09/2006
2	NucleotidesIBA 01/2022 - 02/2006
2	Protein Isoforms (Isoforms)IBA 12/2020 - 09/2006
2	Thrombopoietin ReceptorsIBA 12/2020 - 01/2017
2	Alemtuzumab (Campath)FDA Link 01/2019 - 01/2012
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2018 - 04/2002
2	Complementarity Determining Regions (Complementarity Determining Region)IBA 01/2018 - 05/2002
2	Sirolimus (Rapamycin)FDA Link 10/2017 - 03/2009
2	Oxygen (Dioxygen)IBA 01/2016 - 05/2011
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2015 - 12/2009
2	fludarabineIBA 09/2014 - 05/2006
2	Membrane Proteins (Integral Membrane Proteins)IBA 01/2014 - 12/2004
2	DNA (Deoxyribonucleic Acid)IBA 05/2011 - 05/2003
2	Biological ProductsIBA 03/2011 - 08/2002
2	AndrogensIBA 09/2009 - 09/2009
2	PerforinIBA 04/2009 - 06/2007
2	Messenger RNA (mRNA)IBA 09/2007 - 07/2007

Therapy/Procedure

24	Therapeutics 11/2022 - 02/2002
10	Stem Cell Transplantation 03/2017 - 02/2002
7	Transplantation 03/2017 - 05/2006
4	Drug Therapy (Chemotherapy) 10/2009 - 10/2006
3	Aftercare (After-Treatment) 01/2018 - 12/2010
3	Cell Transplantation 09/2014 - 05/2006
2	Immunotherapy 01/2018 - 08/2005
2	Homologous Transplantation 03/2017 - 07/2012
2	Hematopoietic Stem Cell Transplantation 08/2012 - 05/2008
2	Retreatment 06/2006 - 04/2002